Factor VII (7) deficiency is an inherited bleeding disorder caused when a person’s body does not produce enough of a protein in the blood (factor VII or FVII) that helps blood clot or the factor VII doesn’t work properly. The disorder is very rare, affecting one in 500,000 people. Usually both parents must carry the gene alteration causing the disorder and pass it onto their child for their child to have the disorder. It affects both males and females.
A non-inherited type of factor VII deficiency may also be acquired through liver disease, low levels of vitamin K, or from other problems with absorption. It can also develop in people who take warfarin, a medication that prevents blood clotting.
Links to selected resources:
What Is Factor VII Deficiency?
(World Federation of Hemophilia)
Explains the causes of this bleeding disorder, its symptoms, diagnosis and treatment.
Factor VII deficiency
(Canadian Hemophilia Society, 2001)
This booklet describes factor VII deficiency, what causes it, how it is passed on, severity, diagnosis, symptoms, treatments, specific problems for women, healthy living and preventing bleeds.
Factor VII deficiency
(National Hemophilia Foundation, USA)
Source: What are rare clotting factor deficiencies? World Federation of Hemophilia, Montreal, Canada, 2023.
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